A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method.

A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method† †Dedicated to Prof. Al Padwa, a scholar and a sportsman who has reached pinnacles in both science and sport, on the occasion of his 80th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c7ra06045a Click here for additional data file.

A nucleoside triphosphate for site-specific labelling of DNA by the Staudinger ligation.

A novel nucleotide building block for enzymatic synthesis of azide modified DNA and subsequent conjugation via Staudinger ligation was developed.

An inward current induced by a putative cyclic nucleotide-gated channel in rat cerebellar Purkinje neurons

The roles of cyclic nucleotide-gated (CNG) channels in sensory transduction have long been recognized. More recent studies found that CNG channels are distributed in multiple brain regions involved in memory and learning, including the cortex, hippocampus and cerebellum. These findings suggest that their functions are not limited to sensory perception, but also to neuronal plasticity phenomena,...

An inward current induced by a putative cyclic nucleotide-gated channel in rat cerebellar Purkinje neurons

The roles of cyclic nucleotide-gated (CNG) channels in sensory transduction have long been recognized. More recent studies found that CNG channels are distributed in multiple brain regions involved in memory and learning, including the cortex, hippocampus and cerebellum. These findings suggest that their functions are not limited to sensory perception, but also to neuronal plasticity phenomena,...

Protein assembly by orthogonal chemical ligation methods.

Chemical synthesis harbors the potential to provide ready access to natural proteins as well as to create nonnatural ones. The Staudinger ligation of a peptide containing a C-terminal phosphinothioester with a peptide containing an N-terminal azide gives an amide with no residual atoms. This method for amide bond formation is orthogonal and complementary to other ligation methods. Herein, we de...